Histamine Receptor Antagonist

Histamine Receptor Antagonists (198):

Cat. No.	Product Name	Effect	Purity

HY-B1296

Promethazine	Antagonist	99.59%
Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects.

HY-19010A

BMY-25368 hydrochloride	Antagonist
BMY-25368 hydrochloride is a histamine H2 receptor antagonist that acts as a gastric acid secretion inhibitor. BMY-25368 hydrochloride competitively antagonizes gastric secretion stimulated by histamine and also antagonizes gastric secretion stimulated by Pentagastrin (HY-A0261), Bethanechol (HY-B0406), and food.

HY-19705B

Adriforant hydrochloride	Antagonist	≥98.0%
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (K_i=2.4 nM) and is also a functional (K_i=1.56 nM) antagonist.

HY-I0021

Bepotastine	Antagonist	98.03%
Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research.

HY-B0640

Epinastine	Antagonist	≥98.0%
Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action.

HY-14537

Latrepirdine dihydrochloride	Antagonist	99.71%
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

HY-15538

Ebrotidine	Antagonist	98.51%
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.

HY-B1303A

Mebhydrolin	Antagonist	99.78%
Mebhydrolin is a specific histamine H₁ receptor antagonist.

HY-B0164

Mizolastine	Antagonist	99.82%
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial.

HY-B0538A

Pemirolast potassium	Antagonist	99.93%
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

HY-B1589A

Carbinoxamine maleate salt	Antagonist	99.81%
Carbinoxamine maleate salt is a histamine H1 receptor antagonist.

HY-19489S

(±)-Levomepromazine-d₆	Antagonist	99.23%
(±)-Levomepromazine-d₆ is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-B2168

Mequitazine	Antagonist	99.99%
Mequitazine is a potent, and long-acting histamine H₁ antagonist.

HY-17610

Enerisant	Antagonist	99.79%
Enerisant is a potent, highly selective, competitive and orally active histamine H₃ receptor antagonist/inverse agonist with IC₅₀s of 2.89 nM and 14.5 nM against human and rat histamine H₃ receptors, respectively.

HY-109074

Seliforant	Antagonist
Seliforant (SENS-111) is a selective and orally histamine H4 receptor antagonist.

HY-120124

Samelisant	Antagonist	98.65%
Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; K_i=8.7 nM) and rat (rH3R;K_i=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders.

HY-30234S

Clemizole-d₄	Antagonist	99.82%
Clemizole-d4 is a deuterium labeled Clemizole. Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication.

HY-11044

PF-03654746 Tosylate	Antagonist	99.65%
PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD).

HY-B0298AS

Clemastine-d₅ fumarate	Antagonist	99.48%
Clemastine-d₅ (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

HY-105542

Niaprazine	Antagonist	99.67%
Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research.

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